The dog as an animal model for gastric Helicobacter spp. infection
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چکیده
The gastric mucosa of dogs is often colonized by non-Helicobacter pylori helicobacters (NHPH), while H. pylori is the predominant gastric Helicobacter species in humans. The colonization of the human stomach by H. pylori is highly dependent on the recognition of host glycan receptors. Our goal was to define the canine gastric mucosa glycophenotype, to evaluate the capacity of different gastric Helicobacter species to adhere to the canine gastric mucosa and correlate these data with those obtained in dogs spontaneously infected with the different NHPH. This study provides an important contribution to the epidemiology of Helicobacter spp. infection and to the molecular mechanisms underlying dog-related Helicobacter spe-
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